Publications by authors named "J-M Gracies"
Article Synopsis
- Tremor is the most common movement disorder, and while oral medications often have limited effectiveness due to side effects, botulinum toxin (BT) shows promise for improving upper limb function, although strong evidence is still lacking.
- A systematic review analyzed existing studies on BT for upper-limb tremor, finding only eight randomized controlled trials and seven open-label studies with small sample sizes, indicating that tailored injections based on individual needs lead to better outcomes.
- While BT injections can improve functionality, they may cause temporary weakness, particularly in wrist and finger movements; the review suggests optimizing injection techniques to minimize weakness and enhance effectiveness in treating tremors.
Background And Purpose: Guided self-rehabilitation contracts (GSCs) are a diary-based rehabilitation strategy, wherein specific muscles are identified for prescription of high-load, home self-stretching techniques. We assessed the effect of GSCs combined with simultaneous upper limb (UL) and lower limb (LL) abobotulinumtoxinA injections on composite active range of motion (CXA) in adults with chronic spastic paresis.
Methods: This was an international, prospective, single-arm, open-label study (ENGAGE, NCT02969356).
Objective: The aim of this study is to evaluate a novel composite measure of active range of motion (X) and determine whether this measure correlates with active function.
Design: Post hoc analysis of two randomized, placebo-controlled, double-blind studies with open-label extensions exploring changes in active function with abobotulinumtoxinA.
Setting: Tertiary rehabilitation centers in Australia, Europe, and the United States.