Publications by authors named "J-M Buys"
Physical Activity during Adolescence and Early Adulthood and Breast Cancer Risk before Age 40 Years.
Cancer Epidemiol Biomarkers Prev
January 2025
Article Synopsis
- The study investigates the relationship between recreational physical activity (RPA) in adolescence and early adulthood and breast cancer (BC) risk in women under 40 years old, using data from a large international family cohort.
- Results indicate that higher levels of RPA are linked to reduced BC risk, with a 12% lower risk during adolescence and a 16% lower risk during early adulthood for women in the highest activity quartiles.
- The findings suggest that encouraging more physical activity in young women could be a crucial strategy for lowering the increasing incidence of breast cancer in this age group.
Article Synopsis
- Prolonged high-fat diets worsen cardiovascular, renal, and metabolic health in hypertensive rats with altered kidney development, leading to increased blood pressure and fat accumulation.
- The study tested the effects of a sodium-glucose cotransporter 2 (SGLT2) inhibitor (empagliflozin) alongside a soluble guanylate cyclase (sGC) stimulator (praliciguat) to see if their combination would improve health outcomes in these rats.
- Results showed that the combination therapy significantly reduced blood pressure, improved glucose tolerance, and decreased weight gain, indicating a more effective approach to treating the negative effects of a high-fat diet in hypertension compared to using either drug alone.