Publications by authors named "J-M Brunel"
Article Synopsis
- This study investigates the effectiveness of intravenous thrombolysis (IVT) in treating large-vessel occlusion strokes, particularly focusing on how thrombus composition affects its success in patients receiving mechanical thrombectomy.
- Researchers analyzed the thrombi from 104 stroke patients, using advanced mass spectrometry and liquid chromatography to assess factors influencing fibrin content and fibrinolytic activity (FA).
- Results showed that fibrin-rich thrombi responded better to the recombinant tissue-type plasminogen activator (r-tPA) treatment, while the presence of erythrocytes and neutrophils negatively impacted FA, indicating the complexity of thrombus structure in treatment outcomes.
Background: Autosomal dominant polycystic kidney disease is the most frequent hereditary kidney disease and is generally due to mutations in and , encoding polycystins 1 and 2. In autosomal dominant polycystic kidney disease, hypertension and cardiovascular disorders are highly prevalent, but their mechanisms are partially understood.
Methods: Since endothelial cells express the polycystin complex, where it plays a central role in the mechanotransduction of blood flow, we generated a murine model with inducible deletion of in endothelial cells (;) to specifically determine the role of endothelial polycystin-1 in autosomal dominant polycystic kidney disease.
Background: Throughout the inflammatory response that accompanies atherosclerosis, autoreactive CD4 T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein B (apoB), the core protein of low-density lipoprotein, is an autoantigen that drives the generation of pathogenic T-helper type 1 (T1) cells with proinflammatory cytokine secretion. Clinical data suggest the existence of apoB-specific CD4 T cells with an atheroprotective, regulatory T cell (T) phenotype in healthy individuals.
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