Publications by authors named "J-L Wemeau"
Article Synopsis
- - The study evaluated the safety of a reformulated levothyroxine sodium in France, prompted by a request for stricter potency specifications, after an increase in reported adverse events despite previous bioequivalence and purity assurance.
- - Data from safety reports were collected for both old and new formulations, showing a stark increase in total reports for the new formulation, but with most adverse events being non-serious and rates generally comparable between the two formulations.
- - The analysis concluded that the new formulation has a safety profile similar to the old one, indicating that the overall benefits of the new treatment still outweigh the risks associated with its use.
Context: RTHα is a recently discovered resistance to thyroid hormone (RTH) due to mutation of THRA, the gene encoding TRα1, the thyroid hormone receptor. It has been described in a few patients with growth retardation, short stature, and a low free T4/free T3 (FT4/FT3) ratio.
Objective: A 27-year-old patient presenting with dwarfism and a low FT4/FT3 ratio was investigated.