Publications by authors named "J-L Stephan"
Article Synopsis
- GWAS utilizing mass spectrometry-based proteomics (MS) are vital for drug discovery, addressing limitations of traditional affinity proteomics that restrict analysis to specific protein panels.
- The study analyzed blood samples from 1,260 Americans and 325 individuals from Asia, identifying 252 pQTLs—90 of which were replicated, including 30 previously unreported variants.
- Results showed that about one-third of affinity proteomics pQTLs may be influenced by epitope effects, demonstrating the need for diverse proteomics techniques to uncover previously inaccessible pQTLs.
The synergy between free electrons and light has recently been leveraged to reach an impressive degree of simultaneous spatial and spectral resolution, enabling applications in microscopy and quantum optics. However, the required combination of electron optics and light injection into the spectrally narrow modes of arbitrary specimens remains a challenge. Here, we demonstrate microelectronvolt spectral resolution with a sub-nanometer probe of photonic modes with quality factors as high as 10.
View Article and Find Full Text PDFObjective: High blood pressure is one of the main modifiable risk factors for dementia. However, there is conflicting evidence regarding the best antihypertensive class for optimizing cognition. Our objective was to determine whether any particular antihypertensive class was associated with a reduced risk of cognitive decline or dementia using comprehensive meta-analysis including reanalysis of original participant data.
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