Publications by authors named "J-L Pretet"
FMS-related tyrosine kinase 3 ligand (FLT3L), encoded by FLT3LG, is a hematopoietic factor essential for the development of natural killer (NK) cells, B cells, and dendritic cells (DCs) in mice. We describe three humans homozygous for a loss-of-function FLT3LG variant with a history of various recurrent infections, including severe cutaneous warts. The patients' bone marrow (BM) was hypoplastic, with low levels of hematopoietic progenitors, particularly myeloid and B cell precursors.
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- The study looks at a patient and their relatives who have unusual skin growths caused by human papilloma virus (HPV).
- The patients have a specific genetic change that makes a part of their immune cells (T cells) not work properly, which affects how their body fights off HPV.
- Even though their T cells don’t respond well to HPV, the patients can still make antibodies against the viruses, showing that they can fight infections differently than expected.