Cortical hubs and subcortical cholinergic pathways as neural substrates of poststroke dementia.

Background And Purpose: A role of neural networks in the development of poststroke dementia has not been clearly established. We hypothesized that stroke-mediated disruption of subcortical cholinergic pathway or large-scale neural networks contributes to poststroke dementia.

Methods: A matched case-control study was conducted in a predetermined cohort with acute ischemic stroke.

Impact of both ends of the hemoglobin range on clinical outcomes in acute ischemic stroke.

Background And Purpose: Although both ends of the hemoglobin range may negatively influence clinical outcomes in acute ischemic stroke, most studies have examined the linear relationship or focused on the lower end of the range. Furthermore, it is unclear whether hemoglobin concentrations at different time points during hospitalization correlate with clinical outcomes in the same manner.

Methods: We identified 2681 consecutive patients with acute ischemic stroke from a prospective stroke registry database and grouped them into hemoglobin concentration quintiles using the following 5 indices: initial, nadir, time-averaged, discharge hemoglobin, and hemoglobin drop.

Built-in voltage in organic light-emitting diodes with a use of Li2O/Al cathode.

An effect of bilayer cathode Li2O/Al system was studied in Alq3 based organic light-emitting diodes with a variation of Li2O layer thickness from 0 to 10 nm. The device was made in a structure of ITO/(TPD)/Alq3/Li2O/Al. Current density-luminance-voltage (J-L-V) characteristics and a built-in voltage of the device were measured at ambient conditions.

Enhanced striatal dopamine release during food stimulation in binge eating disorder.

Subjects with binge eating disorder (BED) regularly consume large amounts of food in short time periods. The neurobiology of BED is poorly understood. Brain dopamine, which regulates motivation for food intake, is likely to be involved.

Structure-based chemical modification strategy for enzyme replacement treatment of phenylketonuria.

Structure-based protein engineering coupled with chemical modifications (e.g., pegylation) is a powerful combination to significantly improve the development of proteins as therapeutic agents.