Publications by authors named "J-L Golmard"
Objective: To compare the benefits and risks of lithium therapy vs abstention/other treatments in Kleine-Levin syndrome (KLS).
Methods: In a KLS cohort followed in a single center, 130 patients regularly took lithium carbonate (median dose 1,000 mg/day; n = 71; 40 children), valproate (n = 5), contraceptive pill (n = 5), or no treatment (n = 49). The disease characteristics (frequency, mean, and longest durations of episodes, time incapacitated per year) were compared before and after follow-up in the lithium vs abstention groups.
Article Synopsis
- - The study aimed to identify mutations in two genes, DCC and RAD51, in individuals with congenital mirror movements (CMM), analyzing both familial and simplex cases.
- - Researchers conducted thorough neurological assessments, performed Sanger sequencing, and used a quantitative method to detect gene changes, comparing their findings to a control group.
- - They discovered novel mutations in the DCC gene associated with CMM, with a significant difference in the frequency of harmful variants between patients and controls, indicating a strong link between these genes and CMM, though more genes likely contribute to the condition.
Objective: To further determine the causes of variable outcome from deep brain stimulation of the subthalamic nucleus (DBS-STN) in patients with Parkinson disease (PD).
Methods: Data were obtained from our cohort of 309 patients with PD who underwent DBS-STN between 1996 and 2009. We examined the relationship between the 1-year motor, cognitive, and psychiatric outcomes and (1) preoperative PD clinical features, (2) MRI measures, (3) surgical procedure, and (4) locations of therapeutic contacts.