Publications by authors named "J-L Dumont"
Article Synopsis
- * Researchers developed a novel monoclonal antibody (mAb) called "mAbtyrin" that targets multiple bacterial processes, enhancing its effectiveness against S. aureus.
- * mAbtyrin showed improved protection in preclinical models, including better defense against infections and enhanced effectiveness when used with vancomycin, suggesting it could be a promising treatment for S. aureus-related diseases.
The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) regulates nuclear-factor-kappa-B (NF-κB) activation downstream of surface receptors with immunoreceptor tyrosine-based activation motifs (ITAMs), such as the B-cell or T-cell receptor and has thus emerged as a therapeutic target for autoimmune diseases. However, recent reports demonstrate the development of lethal autoimmune inflammation due to the excessive production of interferon gamma (IFN-ɣ) and defective differentiation of regulatory T-cells in genetically modified mice deficient in MALT1 paracaspase activity. To address this issue, we explored the effects of pharmacological MALT1 inhibition on the balance between T-effector and regulatory T-cells.
View Article and Find Full Text PDFBackground and Purpose- Mechanical thrombectomy has been shown to improve clinical outcomes in patients with acute ischemic stroke. However, the impact of balloon guide catheter (BGC) use is not well established. Methods- STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter study of patients with large vessel occlusion treated with the Solitaire stent retriever as first-line therapy.
View Article and Find Full Text PDFInterhospital Transfer Before Thrombectomy Is Associated With Delayed Treatment and Worse Outcome in the STRATIS Registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke).
Circulation
December 2017
Background: Endovascular treatment with mechanical thrombectomy (MT) is beneficial for patients with acute stroke suffering a large-vessel occlusion, although treatment efficacy is highly time-dependent. We hypothesized that interhospital transfer to endovascular-capable centers would result in treatment delays and worse clinical outcomes compared with direct presentation.
Methods: STRATIS (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke) was a prospective, multicenter, observational, single-arm study of real-world MT for acute stroke because of anterior-circulation large-vessel occlusion performed at 55 sites over 2 years, including 1000 patients with severe stroke and treated within 8 hours.
Article Synopsis
- Mechanical thrombectomy with stent retrievers is now standard for treating acute ischemic stroke due to large vessel occlusion, as shown by the STRATIS registry which aimed to evaluate real-world treatment outcomes compared to randomized trials.
- The study involved 984 patients treated within 8 hours of symptom onset at 55 sites in the U.S., finding key metrics such as a median arrival-to-puncture time of 138 minutes and an 87.9% success rate in achieving sufficient blood flow restoration.
- At 90 days post-treatment, 56.5% of patients had a favorable recovery, but delays in treatment increased the risk of worse outcomes, highlighting the need for improved care systems to enhance patient results.
Background: We aimed to determine the incidence, predictors, clinical characteristics, management, and outcomes of infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI).
Methods And Results: This multicenter registry included 53 patients (mean age, 79±8 years; men, 57%) who suffered IE after TAVI of 7944 patients after a mean follow-up of 1.1±1.
Background: Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients.
Methods And Results: A total of 1556 consecutive patients without prior PPI undergoing transcatheter aortic valve implantation were included.
Background: There is scant information on the prevalence and factors associated with preoperative anemia in patients undergoing transcatheter aortic valve implantation (TAVI) and whether it is associated with mortality. We sought to determine the prevalence and factors associated with preoperative anemia in addition to the prognostic effects of the various levels of preoperative hemoglobin level on mortality in patients undergoing TAVI.
Methods And Results: Ten-center observational study encompassing 1696 patients with aortic stenosis who underwent TAVI was conducted.