Publications by authors named "J-L D'Hondt"
The robotic platform enables surgeons to operate with a similar level of freedom and control as in open surgery, while still providing the patient with the benefits of a minimally invasive approach. More centres continue to adopt robotic liver surgery however standardized training materials and consensus on the surgical technique are currently lacking. The availability of a standardized surgical protocol could benefit the further dissemination of the robotic approach while promoting safe and effective operating techniques.
View Article and Find Full Text PDFProBio is the first outcome-adaptive platform trial in prostate cancer utilizing a Bayesian framework to evaluate efficacy within predefined biomarker signatures across systemic treatments. Prospective circulating tumor DNA and germline DNA analysis was performed in patients with metastatic castration-resistant prostate cancer before randomization to androgen receptor pathway inhibitors (ARPIs), taxanes or a physician's choice control arm. The primary endpoint was the time to no longer clinically benefitting (NLCB).
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- There is a lack of international studies on the outcomes of minimally invasive pancreatoduodenectomy (MIPD), prompting the establishment of the European Registry for Minimally Invasive Pancreatic Surgery (E-MIPS) to monitor these procedures in Europe.
- An analysis of 1,336 patients from 45 centers across 14 European countries indicated significant outcomes, including a major morbidity rate of 41.2% and a 30-day/in-hospital mortality rate of 4.5%.
- Findings revealed that robot-assisted MIPD (R-MIPD) is becoming more popular than laparoscopic MIPD (L-MIPD), with better outcomes in terms of major morbidity and lower rates of complications when performed
Background And Objectives: Limb-girdle muscular dystrophy autosomal recessive type 12 (LGMDR12) is a rare hereditary muscular dystrophy for which outcome measures are currently lacking. We evaluated quantitative MRI and clinical outcome measures to track disease progression to determine which tests could be useful in future clinical trials to evaluate potential therapies.
Methods: We prospectively measured the following outcome measures in all participants at baseline and after 1 and 2 years: 6-minute walk distance (6MWD), 10-meter walk test (10MWT), the Medical Research Council (MRC) sum scores, Biodex isometric dynamometry, serum creatine kinase, and 6-point Dixon MRI of the thighs.