Publications by authors named "J-L Cunha"
Liraglutide is a long-acting glucagon-like peptide-1 receptor agonist prescribed to diabetic patients for glycaemic control. To understand the impact of liraglutide in the real-world setting, this study analysed its effects in a Portuguese cohort of Type 2 diabetes patients. This was an observational, multicentric, and retrospective study that included 191 liraglutide-treated patients with at least 12 months of treatment.
View Article and Find Full Text PDFProvoked by sterile/nonsterile insults, prolonged monocyte mobilization and uncontrolled monocyte/macrophage activation can pose imminent or impending harm to the affected organs. Curiously, folate receptor beta (FRβ), with subnanomolar affinity for the vitamin folic acid (FA), is upregulated during immune activation in hematopoietic cells of the myeloid lineage. This phenomenon has inspired a strong interest in exploring FRβ-directed diagnostics/therapeutics.
View Article and Find Full Text PDFArticle Synopsis
- * Using various methods, researchers reveal that the age and sex of human cases indicate the virus is being transmitted from wild animals (sylvatic transmission) and expanding into new regions previously free of YFV.
- * The study provides a real-time monitoring framework for YFV transmission, aiming to support global efforts in preventing future outbreaks of the virus.
Article Synopsis
- Optical control of heart muscle presents a more precise alternative to traditional electrical stimulation and offers better temporal resolution compared to drug interventions.
- Anion channelrhodopsins (ACRs) from cryptophyte algae can inhibit cardiomyocyte activity with significantly lower light intensity than previous tools like archaerhodopsin-3 (Arch), allowing for more effective control.
- The ability of ACRs to shorten the action potential duration upon light activation during the repolarization phase opens new avenues for research and treatment of cardiac conditions, including long QT syndrome.