Obesity hypoventilation syndrome (OHS) is defined as a combination of obesity (body mass index ≥30 kg·m), daytime hypercapnia (arterial carbon dioxide tension ≥45 mmHg) and sleep disordered breathing, after ruling out other disorders that may cause alveolar hypoventilation. OHS prevalence has been estimated to be ∼0.4% of the adult population.
View Article and Find Full Text PDFPatient-centred outcomes are significantly modified by long-term home noninvasive ventilation (NIV), but a short, self-administered, specific tool for routine clinical assessment is lacking. The aim of this study was to develop and validate the S-NIV questionnaire, a short questionnaire to measure respiratory ymptoms, leep quality and NIV-related ide effects.Patients with stable disease who were under long-term home NIV were recruited from three outpatient NIV services.
View Article and Find Full Text PDFMaximal aerobic capacity is a strong health predictor and peak oxygen consumption (') is considered a reflection of total body health. No systematic reviews or meta-analyses to date have synthesised the existing data regarding ' in patients with obstructive sleep apnoea (OSA).A systematic review of English and French articles using PubMed/MEDLINE and Embase included studies assessing ' in OSA patients either in mL·kg·min compared with controls or in % predicted.
View Article and Find Full Text PDFSertoli cells (SCs), the only somatic cells within seminiferous tubules, associate intimately with developing germ cells. They not only provide physical and nutritional support but also secrete factors essential to the complex developmental processes of germ cell proliferation and differentiation. The SC transcriptome must therefore adapt rapidly during the different stages of spermatogenesis.
View Article and Find Full Text PDFWe assessed the effects of exercise training and non-invasive ventilation (NIV) during exercise in patients with restrictive disorders. Sixteen patients underwent an 8-week home-based cycle exercise program. Nine patients exercised with and seven without NIV.
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