Publications by authors named "J-L Auguste"
Article Synopsis
- Clinical clearance of a child's cervical spine after trauma is difficult due to unreliable neurologic exams; LSMRI may help by providing a quicker, anesthesia-free alternative to standard MRI for detecting ligamentous injuries.
- A study conducted over five years across 10 centers evaluated 2,663 children and found that LSMRI had a sensitivity and negative predictive value of over 99% for detecting cervical spine injuries and 100% for unstable injuries.
- The findings support the use of limited-sequence MRI to effectively rule out significant injuries, suggesting that trauma centers implement LSMRI protocols to reduce the need for anesthesia and MRI times.
Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotypes to identify quantitative trait loci for expression (eQTLs) and splicing (sQTLs) in coronary arteries from 138 ancestrally diverse Americans.
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- Coronary artery disease (CAD) involves the buildup of atherosclerotic plaques in arteries, with complex interactions between vascular and immune cells contributing to its progression.
- This study integrates data from 22 single-cell RNA sequencing libraries, analyzing 118,578 cells to map human atherosclerosis and to better understand cell diversity and communication.
- Key findings include the identification of smooth muscle cell (SMC) markers linked to CAD and atherosclerosis progression, which were validated through various analyses, aiming to inform future cardiovascular research.
Background: Genome-wide association studies have identified hundreds of loci associated with common vascular diseases, such as coronary artery disease, myocardial infarction, and hypertension. However, the lack of mechanistic insights for many GWAS loci limits their translation into the clinic. Among these loci with unknown functions is -four-and-a-half LIM (LIN-11, Isl-1, MEC-3) domain 5 (; chr6q16.
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