Publications by authors named "J-J Morand"
Article Synopsis
- The study aimed to determine if achieving Lupus Low Disease Activity State (LLDAS) leads to better outcomes for patients with newly diagnosed systemic lupus erythematosus (SLE).
- Data was collected from a longitudinal SLE cohort in 13 countries, focusing on patients diagnosed within the last year, revealing that these patients had higher disease activity and use of glucocorticoids, but less organ damage initially compared to older patients in the study.
- Results showed that while fewer patients in the recent onset group were in LLDAS at the start, they were more likely to achieve it during follow-up and LLDAS attainment was linked to a lower risk of disease flare-ups.
Article Synopsis
- Systemic lupus erythematosus (SLE) is a serious autoimmune disease driven by type I interferon (IFN), particularly produced by plasmacytoid dendritic cells (pDCs).
- Research using the anti-CD123 antibody CSL362 showed that depletion of pDCs reduced IFNα production and gene transcription linked to SLE when stimulated with SLE patient blood.
- The study suggests pDCs play a crucial role in SLE pathology by influencing cellular activation and the production of proteins associated with disease severity.
