Publications by authors named "J-J Feige"
Article Synopsis
- High salt (HS) intake can worsen immune responses and contribute to the development of hypertensive vascular diseases, particularly after exposure to Ang II, a hormone that raises blood pressure.
- In experiments with mice, a short period of HS consumption led to increased inflammation and a higher occurrence of severe vascular issues when combined with Ang II infusion, despite no blood pressure differences between groups.
- The study concludes that transient HS intake triggers a mild immune response that becomes problematic when followed by Ang II exposure, suggesting that HS acts as a precursor to more significant hypertension-related health risks.
Background: Mitochondrial dysfunction has been implicated in sarcopenia. P magnetic resonance spectroscopy (MRS) enables non-invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we assessed muscle energetics in older sarcopenic and non-sarcopenic men and compared with muscle biopsy-derived markers of mitochondrial function.
View Article and Find Full Text PDFRationale: Although many familial cases of pulmonary arterial hypertension exhibit an autosomal dominant mode of inheritance with the majority having mutations in essential constituents of the BMP (bone morphogenetic protein) signaling, the specific contribution of the long-term loss of signal transduction triggered by the BMPR2 (type 2 BMP receptor) remains poorly characterized.
Objective: To investigate the role of BMP9, the main ligand of ALK1 (Activin receptor-like kinase 1)/BMPR2 heterocomplexes, in pulmonary hypertension.
Method And Results: The absence of BMP9 in Bmp9 mice and its inhibition in C57BL/6 mice using neutralizing anti-BMP9 antibodies substantially prevent against chronic hypoxia-induced pulmonary hypertension judged by right ventricular systolic pressure measurement, right ventricular hypertrophy, and pulmonary distal arterial muscularization.
Article Synopsis
- - Pregnancy-induced hypertension diseases include gestational hypertension, preeclampsia, and eclampsia, and their mechanisms are not fully understood.
- - The study investigates the role of endocrine gland-derived vascular endothelial growth factor (EG-VEGF), which is secreted by the placenta and may contribute to pregnancy-induced hypertension if its levels remain elevated beyond the first trimester.
- - Experiments in mice showed that increased EG-VEGF resulted in poor placental function, increased hypoxia, and ultimately led to gestational hypertension and kidney dysfunction, highlighting EG-VEGF's pivotal role in these pregnancy complications.
Article Synopsis
- Prokineticin 1 (PROK1) is important for endometrial receptivity and placental development, yet its potential as a noninvasive biomarker for embryo implantation is still unproven.
- The study aimed to connect PROK1 levels in follicular fluid and fertilization culture media with reproductive outcomes in IVF patients, as well as examine the expression of PROK1 and its receptors in the follicles.
- Results indicated that higher PROK1 levels were associated with successful embryo implantation, showing predictive value, while the expression of the PROK1/PROKR system was confirmed during folliculogenesis.
Adrenocortical cell major secreted protein was purified from the conditioned medium of primary cultures of bovine adrenocortical (BAC) cells. Immunochemical analysis and N-terminal sequencing of the purified protein identified it to alpha 2-macroglobulin (alpha 2-M). It appeared that 15 out of the 17 N-terminal amino acids were conserved between adrenocortical cell major secreted protein and human alpha 2-M.
View Article and Find Full Text PDFTransforming growth factor beta (TGF-beta) at picomolar concentrations has been previously shown to induce striking alterations of bovine adrenocortical cell differentiated functions, without detectable effect on growth activity (Feige, J.J., Cochet, C.
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