Publications by authors named "J-I Pagel"
Objective: Although the investigation on the importance of mitochondria-derived reactive oxygen species (ROS) in endothelial function has been gaining momentum, little is known on the precise role of the individual components involved in the maintenance of a delicate ROS balance. Here we studied the impact of an ongoing dysregulated redox homeostasis by examining the effects of endothelial cell-specific deletion of murine thioredoxin reductase 2 (Txnrd2), a key enzyme of mitochondrial redox control.
Approach And Results: We analyzed the impact of an inducible, endothelial cell-specific deletion of Txnrd2 on vascular remodeling in the adult mouse after femoral artery ligation.
Critical role of platelet glycoprotein ibα in arterial remodeling.
Arterioscler Thromb Vasc Biol
March 2015
Article Synopsis
- The study looked at how platelets help recruit white blood cells to build new blood vessels, which is important for healing.
- Researchers used special mice and imaging techniques to see how platelets interact with these cells in real-time.
- They found that a specific platelet protein called GPIbα is essential for this process, and without it, white blood cells can’t attach well, making healing harder.