Publications by authors named "J-I Liao"
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFFactor XII (FXII) knockdown attenuates catheter thrombosis in rabbits. Because histidine-rich glycoprotein (HRG) modulates FXIIa activity, we hypothesized that HRG depletion would promote catheter thrombosis. To test this, rabbits were given either antisense oligonucleotides (ASOs) against HRG or FXII, a control ASO, or saline.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates whether catheter ablation as a first-line treatment for ventricular tachycardia (VT) during implantable cardioverter defibrillator (ICD) implantation is more effective than standard medical therapy plus ICD in patients with cardiomyopathy.
- - The trial involved 180 patients and found that those in the ablation group showed lower recurrence rates of VT and required fewer ICD shocks compared to the control group over an average follow-up period of 31 months.
- - Results suggest that early ablation may offer significant benefits in reducing VT recurrence and hospitalizations for patients with nonischemic cardiomyopathy, potentially filling a current gap in clinical guidelines.
Background: Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of developmental processes, maintain cellular lineage specification, and can define or stratify types of cancer and other diseases. However, the wide variety of approaches available to interrogate these modifications has created a need for harmonized materials, methods, and rigorous benchmarking to improve genome-wide methylome sequencing applications in clinical and basic research. Here, we present a multi-platform assessment and cross-validated resource for epigenetics research from the FDA's Epigenomics Quality Control Group.
View Article and Find Full Text PDFObjective: To study the chemical constituents from Dichotella gemmacea.
Methods: Chemical constituents were isolated by silica gel and Sephadex LH-20 column chromatography. The structures of the isolated compounds were elucidated through spectroscopic analysis.