Publications by authors named "J-G Marchand"
Article Synopsis
- A study conducted at 25 hospitals compared the effectiveness of two antiseptic solutions (iodine povacrylex and chlorhexidine gluconate) in preventing surgical-site infections during extremity fracture surgeries.
- Results showed that iodine povacrylex led to a lower rate of infections in patients with closed fractures (2.4% vs. 3.3%) but did not show a significant difference for open fractures (6.5% vs. 7.3%).
- Ultimately, the study concluded that iodine povacrylex is a more effective skin antiseptic for closed extremity fractures, resulting in fewer infections compared to chlorhexidine, though both had similar outcomes for reoperations and adverse events.
Article Synopsis
- Two main approaches, two-stage and joint modeling, are used to study the relationship between tumor size data and overall survival (OS) in clinical trials, particularly for non-small cell lung cancer patients.
- A large analysis of clinical trials evaluating atezolizumab showed that while the two-stage approach may underestimate tumor growth's impact on OS compared to joint modeling, both methods accurately predicted OS hazard ratios.
- The two-stage approach effectively captured the benefits of atezolizumab on OS, but more research is needed to see if these findings hold true in smaller studies or other cancer types.