Publications by authors named "J-G Lemos"
Article Synopsis
- * In a study of 982 cancer patients from 2020 to 2023, most received the initial vaccine and one booster, but the uptake for the newer bivalent booster was significantly low at only 30.1%.
- * Despite low booster rates, nearly all participants showed improved immune responses after receiving at least two boosters, and those who got boosted had a lower risk of mortality, highlighting the need for better strategies to encourage vaccinations among this vulnerable group.
Background: Systems of care have been developed across the United States to standardize care processes and improve outcomes in patients with ST-segment-elevation myocardial infarction (STEMI). The effect of contemporary STEMI systems of care on racial and ethnic disparities in achievement of time-to-treatment goals and mortality in STEMI is uncertain.
Methods: We analyzed 178 062 patients with STEMI (52 293 women and 125 769 men) enrolled in the American Heart Association Get With The Guidelines-Coronary Artery Disease registry between January 1, 2015, and December 31, 2021.
Article Synopsis
- Higher levels of growth differentiation factor 15 (GDF-15) are linked to increased rates of cardiovascular death and hospitalization for heart failure across various types of atherosclerotic cardiovascular disease (ASCVD).
- In a meta-analysis involving over 53,000 patients, GDF-15 was shown to have significant prognostic value for major cardiovascular events, particularly in stabilized patients after acute coronary syndrome (ACS) and those with stable ASCVD.
- While GDF-15 can predict risks for myocardial infarction and stroke, this association is not evident in patients experiencing acute coronary syndrome, suggesting its limitations in acute settings.
Article Synopsis
- BCATs are enzymes that initiate the breakdown of essential branched-chain amino acids, producing glutamate, and are important in various cancers.
- Researchers discovered a new class of BCAT1/2 inhibitors, called (trifluoromethyl)pyrimidinediones, through high-throughput screening and structural optimization with X-ray crystallography.
- The top candidate, BAY-069, shows strong cellular activity and excellent selectivity, and along with a control compound (BAY-771), was shared with the Structural Genomics Consortium for further research.
Background: The coronavirus disease 2019 (COVID-19) pandemic has exposed longstanding racial and ethnic inequities in health risks and outcomes in the United States. We aimed to identify racial and ethnic differences in presentation and outcomes for patients hospitalized with COVID-19.
Methods: The American Heart Association COVID-19 Cardiovascular Disease Registry is a retrospective observational registry capturing consecutive patients hospitalized with COVID-19.
American Heart Association COVID-19 CVD Registry Powered by Get With The Guidelines.
Circ Cardiovasc Qual Outcomes
August 2020
Background: In response to the public health emergency created by the coronavirus disease 2019 (COVID-19) pandemic, American Heart Association volunteers and staff aimed to rapidly develop and launch a resource for the medical and research community to expedite scientific advancement through shared learning, quality improvement, and research. In <4 weeks after it was first announced on April 3, 2020, AHA's COVID-19 CVD Registry powered by Get With The Guidelines received its first clinical records.
Methods And Results: Participating hospitals are enrolling consecutive hospitalized patients with active COVID-19 disease, regardless of CVD status.
Fsh-mediated regulation of zebrafish spermatogenesis includes modulating the expression of testicular growth factors. Here, we study if and how two Sertoli cell-derived Fsh-responsive growth factors, anti-Müllerian hormone (Amh; inhibiting steroidogenesis and germ cell differentiation) and insulin-like growth factor 3 (Igf3; stimulating germ cell differentiation), cooperate in regulating spermatogonial development. In dose response and time course experiments with primary testis tissue cultures, Fsh up-regulated igf3 transcript levels and down-regulated amh transcript levels; igf3 transcript levels were more rapidly up-regulated and responded to lower Fsh concentrations than were required to decrease amh mRNA levels.
View Article and Find Full Text PDFBackground: There has been an increasing interest in use of mineralocorticoid receptor antagonists (MRAs) in patients with heart failure with preserved ejection fraction (HFPEF). However, a comprehensive evaluation of MRA effects on left ventricular (LV) structure and function in these patients is lacking. In this meta-analysis, we evaluated the effects of MRAs on LV structure and function among patients with diastolic dysfunction or HFPEF.
View Article and Find Full Text PDFObjective: Increased asymmetrical dimethylarginine (ADMA), a NO synthase inhibitor, and its congener symmetrical dimethylarginine (SDMA), predict cardiovascular and all-cause mortality in at-risk populations. Their prognostic value in the general population remains uncertain. We investigated the correlations of SDMA and ADMA with atherosclerosis and cardiovascular/all-cause mortality in the Dallas Heart Study, a multiethnic probability-based cohort aged 30 to 65 years.
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