Neuroimaging and clinical features in type II (late-onset) Alexander disease.

Objective: To describe the imaging and clinical features in type II (late-onset) Alexander disease (AxD).

Methods: We retrospectively identified all cases of type II AxD evaluated at Mayo Clinic, Rochester from January 1996 to February 2012. Clinical and neuroimaging data abstracted from the record included age at onset of symptoms, age at diagnosis, first symptom, neurologic symptoms, physical/neurologic findings on examination, genetic testing and/or biopsy (if performed), and MRI findings.