Publications by authors named "J-F Moura"
Article Synopsis
- Prognostic biomarkers are important for understanding sporadic desmoid tumors (DT) due to their unpredictable nature; this study focused on gene expression differences between DTs located in the thoracic versus abdominal wall.
- A retrospective analysis of 197 sporadic DT patients showed significant relationships between relapse-free survival (RFS) and factors like tumor size, location, and specific gene mutations, notably the CTNNB1 T41A and S45F mutations.
- Results suggest that tumors in the abdominal wall have a better prognosis compared to extra-abdominal locations, with distinct gene expression profiles influencing cancer pathways related to their behavior and outcomes.
Leveraging human cells as materials precursors is a promising approach for fabricating living materials with tissue-like functionalities and cellular programmability. Here we describe a set of cellular units with metabolically engineered glycoproteins that allow cells to tether together to function as macrotissue building blocks and bioeffectors. The generated human living materials, termed as Cellgels, can be rapidly assembled in a wide variety of programmable three-dimensional configurations with physiologically relevant cell densities (up to 10 cells per cm), tunable mechanical properties and handleability.
View Article and Find Full Text PDFIn the United Nations Decade on Ecosystem Restoration, large knowledge gaps persist on how to increase biodiversity and ecosystem functioning in cash crop-dominated tropical landscapes. Here, we present findings from a large-scale, 5-year ecosystem restoration experiment in an oil palm landscape enriched with 52 tree islands, encompassing assessments of ten indicators of biodiversity and 19 indicators of ecosystem functioning. Overall, indicators of biodiversity and ecosystem functioning, as well as multidiversity and ecosystem multifunctionality, were higher in tree islands compared to conventionally managed oil palm.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to analyze the genetic variations in the survival motor neuron 1 (SMN1) gene among Brazilian patients with spinal muscular atrophy (SMA) and to connect these variants with disease severity.
- Out of 450 patients, the majority (89.3%) had a common deletion in exon 7, while others had a mix of this deletion and additional point mutations, with certain variants being more prevalent in compound heterozygous cases.
- The research concluded that specific variants (c.460C>T and c.5C>G) were linked to milder disease forms, and that the copy number of the gene did not consistently predict disease severity among these patients.*
Article Synopsis
- * Analysis was conducted on 1,965 patients from the CORONADO study, categorizing them into normal weight, overweight, and various obesity classes, revealing significant risks associated with higher BMI for intubation and death by day 7.
- * The findings suggest that while overweight and obesity worsen early COVID-19 prognosis in T2D patients, this negative effect is not observed in patients aged 75 and older, indicating a need for tailored management strategies for older adults.
Article Synopsis
- The study aimed to explore the link between the PCDH12 gene and brain calcifications in a child with a specific genetic variant and other adult patients with brain calcifications.
- Researchers conducted a CT scan on one child and analyzed DNA from 79 patients, including those with known familial brain calcifications and those with unknown causes.
- Findings revealed unique calcification patterns in the child that resemble those seen in in utero infections, and while 3 rare genetic variants were found in unrelated PFBC patients, no definitive connection to PCDH12 was established.