Publications by authors named "J-F Gout"
Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis.
Neurol Neuroimmunol Neuroinflamm
July 2021
Objective: Based on animal models and human studies, there is now strong suspicion that host/microbiota mutualism in the context of gut microbial dysbiosis could influence immunity and multiple sclerosis (MS) evolution. Our goal was to seek evidence of deregulated microbiota-induced systemic immune responses in patients with MS.
Methods: We investigated gut and systemic commensal-specific antibody responses in healthy controls (n = 32), patients with relapsing-remitting MS (n = 30), and individuals with clinically isolated syndromes (CISs) (n = 15).
Article Synopsis
- In Paramecium, during the development from germline to somatic macronuclei, specific genetic elements are deleted, a process guided by small RNAs called scnRNAs produced during meiosis.
- This deletion process explains how mating types are inherited in Paramecium tetraurelia, where the default type O is generated through scnRNA-induced removal of the mtA promoter, while type E relies on mtA expression.
- The findings reveal that different species like Paramecium septaurelia use alternative genetic mechanisms for mating type determination, showcasing the flexible use of scnRNA pathways in regulating genes and passing traits across generations.