Publications by authors named "J-F Aupetit"
Endothelial DLL4 Is an Adipose Depot-Specific Fasting Sensor Regulating Fatty Acid Fluxes.
Arterioscler Thromb Vasc Biol
May 2023
Background: Adaptation of fat depots to change in fuel availability is critical for metabolic flexibility and cardiometabolic health. The mechanisms responsible for fat depot-specific lipid sensing and shuttling remain elusive. Adipose tissue microvascular endothelial cells (AT-EC) regulates bidirectional fatty acid fluxes depending on fed or fasted state.
View Article and Find Full Text PDFArticle Synopsis
- There is ongoing debate about the effectiveness of salt-restricted diets in managing heart failure, with current dietary guidelines lacking consistency and supporting evidence.
- The OFICSel observatory collected data from 2822 patients hospitalized for heart failure, examining the relationship between cardiologists' dietary recommendations and patients’ understanding and adherence to these diets.
- Findings reveal that while 90% of patients received a recommendation for a diet with less than 6g of salt per day, only 33% adhered to it, and restrictive diets increased the perceived burden on patients, indicating a need for more evidence-based dietary guidelines.
Background: Experimental and clinical evidence suggests that cyclosporine may attenuate reperfusion injury and reduce myocardial infarct size. We aimed to test whether cyclosporine would improve clinical outcomes and prevent adverse left ventricular remodeling.
Methods: In a multicenter, double-blind, randomized trial, we assigned 970 patients with an acute anterior ST-segment elevation myocardial infarction (STEMI) who were undergoing percutaneous coronary intervention (PCI) within 12 hours after symptom onset and who had complete occlusion of the culprit coronary artery to receive a bolus injection of cyclosporine (administered intravenously at a dose of 2.