Open lift-drill-fill-fix for medial osteochondral lesions of the talus: surgical technique.

Objective: Osteochondral lesions of the talus (OLT) with a fragment on the talar dome that fail conservative treatment and need surgical treatment can benefit from in situ fixation of the OLT. Advantages of fixation include the preservation of native cartilage, a high quality subchondral bone repair, and the restoration of the joint congruency by immediate fragment stabilization. To improve the chance of successful stabilization, adequate lesion exposure is critical, especially in difficult to reach lesions located on the posteromedial talar dome.

[A man with a painful swelling of the thigh].

A 49-year old male patient presented with a painful swelling of the left thigh after a football trauma. An isolated musculotendinous rectus femoris rupture was diagnosed with ultrasound and MRI. 3 months after surgical repair he was fully recovered in function and strength.

The MITF, p.E318K Variant, as a Risk Factor for Pheochromocytoma and Paraganglioma.

Context: The microphthalmia-associated transcription factor (MITF) regulates the survival, proliferation, and differentiation of neural crest-derived lineages. Recent studies reported an increased risk of melanoma in individuals carrying the rare variant MITF, p.E318K (rs149617956).