Publications by authors named "J-B Morin"
Article Synopsis
- - The study analyzes plasma samples from 318 COVID-19 patients to understand how RNAemia, delayed antibody responses, and inflammation affect patient outcomes, revealing four distinct patient clusters based on severity and survival probability.
- - Critically ill patients were categorized into good prognosis and high-fatality clusters, while non-critical survivors were divided into high and low early antibody responders, each showing different patterns in antibody development and inflammation.
- - The findings indicate that high-fatality patients have specific genomic signatures linked to severe COVID-19, and both critical and non-critical patients with delayed antibody responses exhibit persistent interferon (IFN) activity, suggesting that high IFN levels might hinder the body's ability to build effective immunity.
Introduction: Black and African American (AA) people are over-represented in the kidney failure population; therefore, the safety and efficacy of difelikefalin in Black/AA patients was evaluated.
Methods: This was a post hoc, pooled exploratory subgroup analysis of the Phase 3 KALM-1 and -2 studies. Patients undergoing hemodialysis (HD) who had moderate-to-severe chronic kidney disease-associated pruritus (CKD-aP) at enrollment were stratified into self-reported Black/AA or White subgroups.
Recurrence is a major cause of death among BRCA1/2 mutation carriers with breast (BrCa) and ovarian cancers (OvCa). Herein we perform multi-omic sequencing on 67 paired primary and recurrent BrCa and OvCa from 27 BRCA1/2 mutation carriers to identify potential recurrence-specific drivers. PARP1 amplifications are identified in recurrences (False Discovery Rate q = 0.
View Article and Find Full Text PDFBackground: Aging myocardium undergoes progressive cardiac hypertrophy and interstitial fibrosis with diastolic and systolic dysfunction. Recent metabolomics studies shed light on amino acids in aging. The present study aimed to dissect how aging leads to elevated plasma levels of the essential amino acid phenylalanine and how it may promote age-related cardiac dysfunction.
View Article and Find Full Text PDFJiménez-Reyes, P, Garcia-Ramos, A, Párraga-Montilla, JA, Morcillo-Losa, JA, Cuadrado-Peñafiel, V, Castaño-Zambudio, A, Samozino, P, and Morin, J-B. Seasonal changes in the sprint acceleration force-velocity profile of elite male soccer players. J Strength Cond Res 36(1): 70-74, 2022-This study aimed to describe the seasonal changes in the sprint force-velocity (Fv) profile of professional soccer players.
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- Researchers aimed to standardize a set of 174 radiomic features used in medical imaging due to challenges caused by unstandardized definitions and reference values.
- The study was conducted in three phases, with increasing consensus on feature validity, showing significant improvement in reproducibility across different imaging modalities by the end of the process.
- Ultimately, 169 radiomic features were successfully standardized, which could enhance clinical application and verification in imaging diagnostics.
PD-L1 immunohistochemistry correlates only moderately with patient survival and response to PD-(L)1 treatment. Heterogeneity of tumor PD-L1 expression might limit the predictive value of small biopsies. Here we show that tumor PD-L1 and PD-1 expression can be quantified non-invasively using PET-CT in patients with non-small-cell lung cancer.
View Article and Find Full Text PDFTriclocarban (3,4,4'-trichlorocarbanilide; TCC) is an antibacterial agent used in personal care products such as bar soaps. Small amounts of chemical are absorbed through the epidermis. Recent studies show that residues of reactive TCC metabolites are bound covalently to proteins in incubations with keratinocytes, raising concerns about the potential toxicity of this antimicrobial agent.
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