Publications by authors named "J-B Gros"
C1q binding to surface-bound IgG is stabilized by C1rs proteases.
Proc Natl Acad Sci U S A
June 2021
Article Synopsis
- - Complement plays a crucial role in antibody-mediated clearance of infections and tumor cells by recruiting the C1 complex to target cells, leading to pore formation and phagocytosis.
- - The C1 complex is made up of the recognition protein C1q and proteases C1r and C1s, and the interaction between C1 and IgG-Fc is influenced by the function of C1rs proteases, affecting the stability of the C1q-IgG complex.
- - Engineering antibodies to enhance hexamer formation improves the stability of C1q-IgG interactions and boosts complement-dependent phagocytosis, offering valuable insights for developing better antibody therapies.
Mice of different inbred strains vary in their resistance to intravenous infection with Mycobacterium lepraemurium (MLM). The mean survival time of MLM-infected A/J and DBA/2 mice is significantly longer than that of similarly infected C57BL/6 and BALB/c mice. The typing of AXB/BXA recombinant inbred strains (A = A/J,B = C57BL/6) for the trait of relative resistance/susceptibility to MLM revealed a perfect match with the strain distribution pattern of resistance/susceptibility to Mycobacterium bovis (BCG), the trait which is controlled by the Bcg (Ity, Lsh) locus on chromosome 1.
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