Publications by authors named "J-B Fleury"
Background: Cortical excitation/inhibition dynamics have been suggested as a key mechanism occurring after stroke. Their supportive or maladaptive role in the course of recovery is still not completely understood. Here, we used transcranial magnetic stimulation (TMS)-electroencephalography coupling to study cortical reactivity and intracortical GABAergic inhibition, as well as their relationship to residual motor function and recovery longitudinally in patients with stroke.
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- The study investigates how exposure to PFAS (per- and polyfluoroalkyl substances) during pregnancy and childhood may affect heart and metabolic health in participants from the HOME Study in Cincinnati.
- Researchers identified two PFAS exposure profiles and assessed various health indicators, like insulin resistance and blood pressure, in children at age 12.
- Findings suggest that females exposed to higher levels of PFAS had increased cardiometabolic risks, while males showed lower risks, indicating sex-specific effects of PFAS exposure on adolescent health.
Microhomology-mediated end joining (MMEJ) is an intrinsically mutagenic pathway of DNA double-strand break (DSB) repair essential for proliferation of homologous recombination (HR)-deficient tumors. Although targeting MMEJ has emerged as a powerful strategy to eliminate HR-deficient (HRD) cancers, this is limited by an incomplete understanding of the mechanism and factors required for MMEJ repair. Here, we identify the APE2 nuclease as an MMEJ effector.
View Article and Find Full Text PDFBackground: Most studies on stroke have been designed to examine one deficit in isolation; yet, survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretical methods may open new avenues of understanding.
Methods: Fifty subacute stroke patients (7±3days poststroke) underwent diffusion-weighted magnetic resonance imaging and a battery of clinical tests of motor and cognitive functions.