Publications by authors named "J vd Velde"
Filter-aided extracellular vesicle enrichment (FAEVEr) for proteomics.
Mol Cell Proteomics
January 2025
Extracellular vesicles (EVs), membrane-delimited nanovesicles that are secreted by cells into the extracellular environment, are gaining substantial interest due to their involvement in cellular homeostasis and their contribution to disease pathology. The latter in particular has led to an exponential increase in interest in EVs as they are considered to be circulating packages containing potential biomarkers and are also a possible biological means to deliver drugs in a cell-specific manner. However, several challenges hamper straightforward proteome analysis of EVs as they are generally low abundant and reside in complex biological matrices.
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- Hypoxic tumors resist radiation due to low oxygen levels, which reduces the effectiveness of therapy; increasing oxygenation during treatment could enhance radiosensitivity.
- Historical approaches to boost oxygen delivery to tumors have had limited success, but inhibiting cancer cell respiration may yield better results.
- Research shows that the mitochondria-targeted antioxidant MitoQ can effectively radiosensitize breast tumors in mice, suggesting potential for its use alongside radiotherapy in clinical settings.
Article Synopsis
- - The study investigates the long-term effects of bilateral testicular regression (BTR) in individuals, focusing on growth and development outcomes, particularly highlighting suboptimal penile growth often related to genetic factors.
- - BTR, a rare condition with potential vascular and genetic origins, was analyzed in a cross-sectional study involving 35 participants recruited from eight pediatric endocrinology departments in Belgium over three years.
- - Key findings revealed common maternal complications during pregnancy and identified specific genetic variants in some participants, while a centralized review of gonadal tissue contributed to understanding the condition's clinical implications.
The association of overweight, obesity, and long-term obesity with SARS-CoV-2 infection: a meta-analysis of 9 population-based cohorts from the Netherlands Cohorts Consortium.
Int J Obes (Lond)
October 2024
Background: Obesity may affect an individual's immune response and subsequent risk of infection, such as a SARS-CoV-2 infection. It is less clear whether overweight and long-term obesity also constitute risk factors. We investigated the association between the degree and duration of overweight and obesity and SARS-CoV-2 infection.
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- Hypercoagulability is linked to higher levels of coagulation factors and increased thrombin generation, which could be related to type 2 diabetes and other complications like glucose metabolism issues and endothelial dysfunction.
- The study analyzed data from 5,718 participants, tracking diabetes diagnoses over 6.7 years, and found that higher levels of specific coagulation factors correlated with increased risk of developing type 2 diabetes.
- Although glycoprotein acetylation (GlycA) was examined as a potential mediator in these associations, it only explained a small portion of the relationship, suggesting that hypercoagulability plays a significant role in the development of type 2 diabetes.