Publications by authors named "J van der Heiden"
: The NOL system (PMD-200™ Nociception Level Monitor; Medasense Ltd., Ramat Gan, Israel) is used for the real-time detection of physiological nociception in anesthetized patients by assessing the parameters indicative of sympathetic activity, such as photoplethysmography, skin conductance, peripheral temperature, and accelerometry, which are quantified into the NOL-Index. This index is more sensitive than traditional clinical parameters in estimating pain and stress responses.
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- Systemic sclerosis (SSc) interstitial lung disease (ILD) significantly contributes to health complications and mortality in SSc patients, with tocilizumab (TCZ) showing promise in slowing lung function decline.
- Transcriptome analysis of skin biopsies from clinical trials indicated a gene network connected to disease progression, particularly involving plasma cell (PC) gene expressions linked to the positive effects of TCZ treatment.
- Further investigations, including single-cell RNA sequencing, confirmed that PC signature genes are present in CD38 and CD138 positive cells in SSc lungs, suggesting these genes may play an important role in the progression of the disease and the therapeutic mechanisms of TCZ.
Background: Research has shown that the course of non-specific low back pain (LBP) is influenced by, among other factors, patients' self-management abilities. Therefore, clinical guidelines recommend stimulation of self-management. Enhancing patients' self-management potentially can improve patients' health outcomes and reduce future healthcare costs for non-specific LBP.
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- * This research shows that large-area monocrystalline gold flakes serve as a low-loss, atomically flat substrate, enabling precise near-field measurements of polaritons in these materials.
- * The findings reveal that image phonon-polaritons in hexagonal boron nitride have a parabolic spectral dependence in propagation length, and these modes show significantly longer propagation lengths compared to those on dielectric substrates.
Active metasurfaces have been proposed as one attractive means of achieving high-resolution spatiotemporal control of optical wavefronts, having applications such as LIDAR and dynamic holography. However, achieving full, dynamic phase control has been elusive in metasurfaces. In this paper, we unveil an electrically tunable metasurface design strategy that operates near the avoided crossing of two resonances, one a spectrally narrow, over-coupled resonance and the other with a high resonance frequency tunability.
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