Publications by authors named "J van den Oord"
Article Synopsis
- - Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with increasing rates in the US and Europe, primarily linked to the Merkel cell polyomavirus (MCPyV), although its cell of origin is still uncertain.
- - The study introduced MCPyV antigens into different cancer cell lines to analyze how they affect DNA methylation and gene expression, revealing that MCPyV-LT alters DNA methylation in both cell lines while MCPyV-sT only impacted one.
- - Findings indicate significant changes in gene expression patterns, particularly in MCC13 cells, with downregulated genes in immune pathways suggesting potential targets for new immunotherapies for MCC, along with confirmation that MCPyV-LT regulates gene
Article Synopsis
- Researchers studied the cellular structure of melanoma tumors and their changes when treated with immune checkpoint blockade (ICB) to understand why some patients resist this therapy.
- They found that a specific cell type with a mesenchymal-like (MES) state, which is associated with resistance to treatment, was more common in patients who did not respond to ICB.
- The study identified TCF4 as a key regulator that controls this resistance by suppressing other important immune functions, and targeting TCF4 could enhance the effectiveness of both ICB and other therapies in melanoma treatment.
Purpose: Dedifferentiated melanoma (DedM) poses significant diagnostic challenges. We aimed to investigate the clinical, histopathological and molecular features of DedM. Methylation signature (MS) and copy number profiling (CNP) were carried out in a subgroup of cases.
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