Publications by authors named "J van de Sande"
Background: Catheter ablation of accessory pathway is the treatment of choice for patients with symptomatic Wolff-Parkinson-White (WPW) syndrome. Accessory pathway (AP) identification relies on point-by-point mapping, raising the need for more precise and efficient methods. High-density open window mapping (OWM) combined with the extended early meets late (EEML) algorithm, utilizing 3D electroanatomic mapping systems, is a promising alternative.
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- Peptide hormones undergo important post-translational modifications (PTMs) like tyrosine sulfation, crucial for functions such as plant growth.
- Detecting these modifications, particularly sulfotyrosine, faces challenges in isolation and measurement techniques.
- Nanopore technology can accurately identify and distinguish between different PTMs in single molecules, demonstrating over 90% accuracy in detecting sulfation and phosphorylation of peptide hormones.
Article Synopsis
- Many European countries have established semi-autonomous health agencies to balance public interests, but they face challenges like regulatory capture and alignment with their parent ministries.
- This paper uses q-methodology to explore the perspectives of various stakeholders regarding the National Health Care Institute (Zorginstituut Nederland) in the Dutch healthcare system, based on 41 q-interviews.
- The study identifies three main viewpoints on the agency's focus: addressing societal issues, managing healthcare packages strictly, and ensuring efficient care organization, highlighting how conflicting expectations complicate the agency's role.
Peptide phytohormones are decorated with post-translational modifications (PTMs) that are crucial for receptor recognition. Tyrosine sulfation on these hormones is essential for plant growth and development1. Measuring the occurrence and position of sulfotyrosine is, however, compromised by major technical challenges during isolation and detection2.
View Article and Find Full Text PDFDiffractive optical elements that divide an input beam into a set of replicas are used in many optical applications ranging from image processing to communications. Their design requires time-consuming optimization processes, which, for a given number of generated beams, are to be separately treated for one-dimensional and two-dimensional cases because the corresponding optimal efficiencies may be different. After generalizing their Fourier treatment, we prove that, once a particular divider has been designed, its transmission function can be used to generate numberless other dividers through affine transforms that preserve the efficiency of the original element without requiring any further optimization.
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