Publications by authors named "J van Werven"
Therapy with immune checkpoint inhibitors (ICIs) has significantly improved the prognosis of metastatic melanoma but is also associated with various immune-related adverse events (AE), including pulmonary toxicity. Herein, we describe the case of a 60-year-old female with metastasized melanoma with BRAF mutation under combination immunotherapy with ipilimumab and nivolumab, who presented with a persistent, nonproductive cough for the last two months. Her CT-scan showed de novo bronchial inflammation and wall thickening in all lung fields.
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- The study aimed to evaluate the effectiveness of chest CT and RT-PCR tests for COVID-19 in asymptomatic surgical patients.
- The research involved 2,093 patients across 14 centers, revealing a low positive yield of COVID-19 cases—1.5% for combined testing, 0.7% for CT, and 1.1% for RT-PCR.
- Results indicated that while preoperative screening helped ensure safety in surgeries, the value of chest CT testing was minimal compared to RT-PCR, particularly as community COVID-19 prevalence increased.
Background: Accurate prediction scores for liver steatosis are demanded to enable clinicians to noninvasively screen for nonalcoholic fatty liver disease (NAFLD). Several prediction scores have been developed, however external validation is lacking.
Objective: The aim was to determine the diagnostic accuracy of four existing prediction scores in severely obese children, to develop a new prediction score using novel biomarkers and to compare these results to the performance of ultrasonography.
Purpose: To evaluate the diagnostic accuracy of ultrasonography (US) for the assessment of hepatic steatosis in severely obese adolescents, with proton magnetic resonance (MR) spectroscopy as the reference standard, and to provide insight on the influence of prevalence on predictive values by calculating positive and negative posttest probabilities.
Materials And Methods: This prospective study was institutional review board approved. All participants, and/or their legal representatives, gave written informed consent.
Purpose: To investigate the feasibility of in vivo assessment of hepatic lipid composition using 3.0-T proton magnetic resonance spectroscopy ((1)H-MRS) in a steatotic rat model and compare it to histopathological and biochemical assessment.
Materials And Methods: Hepatic steatosis was induced by feeding rats with a methionine/choline-deficient (MCD) diet for 1, 2, 3, 5 or 7 weeks (n=5 per group).