Publications by authors named "J van Meerbeeck"
Article Synopsis
- Pleural mesothelioma (PM) is a rare and aggressive cancer often diagnosed late, highlighting the need for early detection biomarkers through DNA methylation analysis.
- This study generated a large dataset comparing DNA methylation patterns between healthy pleura and PM, identifying over 81,000 differentially methylated sites, including five key sites linked to specific genes.
- The findings indicate that PM has unique methylation profiles that distinguish it from other lung diseases and may aid in understanding the disease’s progression and offer potential for biomarker development.
Article Synopsis
- This paper talks about problems in cancer treatment in Europe, especially how health guidelines and medical recommendations don’t match up.
- It studied different European countries to see if they use advanced cancer tests that doctors recommend.
- The results showed that many countries are not using these advanced tests, which could help patients more, and the paper suggests that health leaders need to pay more attention to these recommendations for better cancer care.
Background: Dendritic cell immunotherapy has proven to be safe and induces an immune response in humans. We aimed to establish the efficacy of dendritic cells loaded with allogeneic tumour cell lysate (MesoPher, Amphera BV, 's-Hertogenbosch, Netherlands) as maintenance therapy in patients with pleural mesothelioma.
Methods: In this open-label, randomised, phase 2/3 study, patients with histologically confirmed unresectable pleural mesothelioma, aged 18 years or older, with an Eastern Cooperative Oncology Group performance status score of 0-1, and non-progressing disease after four to six cycles of standard chemotherapy (with pemetrexed 500 mg/m plus platinum [cisplatin 75 mg/m or carboplatin area under the curve of 5]) were recruited from four centres in Belgium, France, and The Netherlands.
Background: The role of surgery in pleural mesothelioma remains controversial. It may be appropriate in highly selected patients as part of a multimodality treatment including chemotherapy. Recent years have seen a shift from extrapleural pleuropneumonectomy toward extended pleurectomy/decortication.
View Article and Find Full Text PDFPurpose: CONVERT was a phase 3 international randomized clinical trial comparing once-daily (OD) and twice-daily (BD) radiation therapy (RT). This updated analysis describes the 6.5-year outcomes of these regimens delivered with conformal techniques.
View Article and Find Full Text PDF