Publications by authors named "J de la Torre-Cisneros"
Efficacy of high doses of intravenous fosfomycin for treatment of urinary tract infection caused by KPC carbapenemase-producing Klebsiella pneumoniae. An observational study.
J Glob Antimicrob Resist
December 2024
Objectives: To evaluate the efficacy of high-dose intravenous fosfomycin for the treatment of urinary tract infections (UTI) caused by KPC carbapenemase-producing Klebsiella pneumoniae (KPC-Kp). A secondary objective was to evaluate the impact of the results of fosfomycin susceptibility testing on prognosis.
Methods: This is an observational and retrospective study.
Introduction: Difficult-to-treat-resistant (DTR) infections caused by Pseudomonas aeruginosa represent a global public health threat, prioritizing the search and development of new antibiotics for this microorganism.
Methods: We present the real-life experience of the compassionate use of imipenem/cilastatin/relebactam in a descriptive study involving 14 patients with DTR-P. aeruginosa infection and limited treatment options.
Article Synopsis
- There is a pressing need for new treatments for serious infections caused by Gram-negative bacteria, which the REVISIT study examined by evaluating aztreonam-avibactam against standard treatments in complicated infections.
- The study involved a multinational, open-label design with adults who had complicated intra-abdominal infections or hospital-acquired pneumonia, comparing aztreonam-avibactam with meropenem or colistin over 5-14 days.
- Results showed that out of 422 enrolled patients, 64% had identified Gram-negative pathogens, and the study aimed to determine clinical cure rates and safety without formal hypothesis testing.
Long-Term Clinical and Ecological Impact of an Antimicrobial Stewardship Program on the Incidence of Carbapenem-Resistant Infections in a High-Endemic Hospital.
Antibiotics (Basel)
August 2024
Carbapenem-resistant (CR-Kp) is currently a serious global concern. Antimicrobial stewardship programs (ASPs) are one of the key strategies to overcome this resistance. However, evidence about the long-term clinical and ecological impacts of ASPs is scarce.
View Article and Find Full Text PDFArticle Synopsis
- * A working group has developed new consensus recommendations for CMV management in SOT recipients, integrating recent advancements in cell-mediated immunity monitoring.
- * These recommendations were rated for their evidence strength and quality using the GRADE system and were formally endorsed by a consensus meeting of experts.