Publications by authors named "J de Santiago"
Background: Isotachophoresis (ITP) is a well-established electrokinetic method for separation and preconcentration of analytes. Several simulation tools for ITP have been published, but their use for experimental design is limited by the computational time for a single run and/or by the number of conditions that can be investigated per simulation run. A large fraction of the existing solvers also do not account for ionic strength effects, which can influence whether an analyte focuses in ITP.
View Article and Find Full Text PDFArticle Synopsis
- The study introduces a neo-Hookean elasticity theory for hybrid mechano-active hydrogels by incorporating motor proteins into polymer structures, leading to materials that actively soften due to adjustable chain overlaps.
- The focus is on polyacrylamide hydrogels enhanced with the bacterial protein FtsZ, using a multiscale model that combines microscopic rubber mesh theory, mesoscopic scaling concepts, and phase transition formalism to explain the observed active softening.
- This research provides valuable insights for designing and controlling complex active hydrogels, potentially advancing applications in technology and biomedicine.
Plant endogenous signaling peptides shape growth, development and adaptations to biotic and abiotic stress. Here, we identify C-TERMINALLY ENCODED PEPTIDEs (CEPs) as immune-modulatory phytocytokines in Arabidopsis thaliana. Our data reveals that CEPs induce immune outputs and are required to mount resistance against the leaf-infecting bacterial pathogen Pseudomonas syringae pv.
View Article and Find Full Text PDFArticle Synopsis
- Clock genes are important for the function of the suprachiasmatic nucleus (SCN) and also play roles in other brain areas; their expression has been studied in various species to understand their functions better.
- This study focused on the presence of clock genes Per1, Per2, and Cry1 in neurons of the substantia nigra (SN) and subthalamic nucleus (STN) in a diurnal primate, expanding beyond research mainly done on nocturnal rodents.
- Immunohistochemistry revealed significant presence of Per1 and Per2 in the SN and both these genes in the STN, while Cry1 was not detected in the STN, highlighting the role of these genes in areas linked to motor
In this paper, we review some results produced by our research group regarding the role of schedules of reinforcement in social behavior. We discuss data from studies in which we attempted to create conditions in which interdependent gains overlapped with individual reinforcement schedules so that these situations were more or less competitive and conflicting. We argue that normative rules about reinforcement schedules and interdependent reinforcement are crucial for analyzing social behavior since these rules allow us to differentiate the effects of individual and social contingencies or an interaction of both.
View Article and Find Full Text PDF