Publications by authors named "J de Lorgeril"
Pacific oysters face recurring outbreaks of Pacific Oyster Mortality Syndrome (POMS), a polymicrobial multifactorial disease. Although this interaction is increasingly understood, the role of epigenetics (e.g.
View Article and Find Full Text PDFBackground: In holobiont, microbiota is known to play a central role on the health and immunity of its host. Then, understanding the microbiota, its dynamic according to the environmental conditions and its link to the immunity would help to react to potential dysbiosis of aquacultured species. While the gut microbiota is highly studied, in marine invertebrates the hemolymph microbiota is often set aside even if it remains an important actor of the hemolymph homeostasis.
View Article and Find Full Text PDFArticle Synopsis
- - Polymicrobial infections, like Pacific Oyster Mortality Syndrome (POMS), are complex and under-researched, involving interactions between the ostreid herpesvirus 1 (OsHV-1) and harmful bacteria impacting oyster populations on the French Atlantic coast.
- - Field studies and laboratory experiments revealed that certain bacterial communities flourish in oysters infected with OsHV-1 and that these bacteria can enhance the virus's effects, leading to accelerated oyster mortality.
- - Cooperative behaviors among bacteria, including promoting one another’s growth and sharing resources, play a significant role in the severity of POMS, suggesting that targeting these interactions may help manage the disease and protect oyster health.
Article Synopsis
- Disease emergence is increasing due to global changes, making it crucial to understand how host populations adapt rapidly, particularly in the context of Pacific oyster mortality syndrome (POMS).
- The study used (epi)genome-wide association mapping to reveal that oysters exposed to POMS showed signs of genetic and epigenetic selection, particularly in genes related to immunity.
- Results indicated that about one-third of the phenotypic variation in response to POMS could be attributed to interactions between genetic and epigenetic factors, highlighting the significant role of both in rapid adaptation to infectious diseases.
Article Synopsis
- The Pacific oyster Crassostrea gigas faces a deadly condition known as Pacific Oyster Mortality Syndrome (POMS), triggered by the herpesvirus OsHV-1 µVar, leading to an opportunistic bacterial infection.
- Researchers combined metabarcoding and metatranscriptomic techniques to investigate POMS, discovering a consistent progression of disease and identifying a core group of bacteria that, along with the virus, contribute to the syndrome.
- The identified bacteria exhibit low competition for nutrients, which might enhance their ability to colonize the oyster's tissues and maintain the POMS pathobiota despite varying environmental challenges.