[Indexing to Body Surface Area Diminishes GFR Estimation and Increases Chronic Kidney Disease Staging in Overweight and Obese Population].

Unlabelled: Glomerular filtration rate estimates are usually indexed to a standard body surface area (BSA) of 1.73 m2. This allows comparing values of individuals of different sizes but has the potential of affecting individuals with extremes BSA.

Significance of cycle 1 bone marrow biopsy in predicting outcomes and toxicities of venetoclax-based therapy for myeloid malignancies.

For older unfit patients receiving venetoclax-based induction, data on the significance of interim bone marrow biopies (BMBx) findings on clinical outcomes is lacking. We retrospectively evaluated interim BMBx results performed on Cycle 1 days 21-28 of venetoclax-based therapy in 69 adults with myeloid malignancies to determine whether blast clearance was associated with overall survival (OS) and overall response rate (ORR). Median age was 75 years (range 69-78).

Navigating from cellular phenotypic screen to clinical candidate: selective targeting of the NLRP3 inflammasome.

The NLRP3 inflammasome plays a pivotal role in host defense and drives inflammation against microbial threats, crystals, and danger-associated molecular patterns (DAMPs). Dysregulation of NLRP3 activity is associated with various human diseases, making it an attractive therapeutic target. Patients with NLRP3 mutations suffer from Cryopyrin-Associated Periodic Syndrome (CAPS) emphasizing the clinical significance of modulating NLRP3.

Physiological responses of the alien macroalga Rugulopteryx okamurae (Phaeophyceae, Heterokontophyta) to changes in nutrients and temperature.

The Asian brown macroalga Rugulopteryx okamurae has invaded the oligotrophic areas of Mediterranean coasts since 2015, with drastic impacts on environmental conditions and socioeconomic activities in coastal areas in Europe. Therefore, it is intriguing how this species is able to grow and expand at the observed rates. In this context, the physiological responses of R.