Publications by authors named "J de Castilhos"
Background: This study explored the layperson's perception of comfort, satisfaction, and willingness to use various accessories in clear aligner therapy.
Methods: A total of 267 people analyzed standardized intraoral photographs of a female model in orthodontic treatment using: 1) only clear aligner (CA), the control group; 2) clear aligner+attachments (AT); 3) clear aligners+Cl II elastics (EL); 4) clear aligner+hybrid treatment with esthetic braces (HEB); 5) Clear aligner+hybrid treatment with metallic braces (HMB); 6) clear aligner+mini-implants (MI); 7) clear aligner+mini-implants and elastics for intrusion (MIE). In addition, a social media questionnaire was distributed to assess the willingness to undergo orthodontic treatment with various accessories.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a severe cancer known for late diagnoses and high mortality due to its complex biology and treatment resistance.
- This review examines how the microbiome influences the effectiveness of chemotherapy in PDAC by affecting drug metabolism and immune response within the tumor environment.
- It discusses innovative methods like AI and patient-derived models to explore microbial interactions with cancer, emphasizing the need for personalized approaches in treatment to improve patient outcomes.
Article Synopsis
- Recent studies indicate that specific microbiota may influence complications and outcomes in patients undergoing pancreatic head resections.
- *A prospective study involving 101 patients utilized 16S rRNA sequencing to investigate the microbiome at surgical sites and found that variations in microbiome composition were linked to factors such as cancer type, age, and pre-surgical interventions.
- *In particular, higher levels of Enterococcus spp. in the bile were associated with increased risk of surgical site infections and higher mortality rates up to 24 months post-surgery.*