Publications by authors named "J de Bresser"
Background: Cerebrospinal fluid (CSF) motion and pulsatility has been proposed to play a crucial role in clearing brain waste. Although its driving forces remain debated, increasing evidence suggests that large amplitude vasomotion drives such CSF fluctuations. Recently, a fast blood-oxygen-level-dependent (BOLD) fMRI sequence was used to measure the coupling between CSF fluctuations and low-frequency hemodynamic oscillations in the human cortex.
View Article and Find Full Text PDFDynamic susceptibility contrast (DSC) MRI is commonly part of brain tumor imaging. For quantitative analysis, measurement of the arterial input function and tissue concentration time curve is required. Usually, a linear relationship between the MR signal changes and contrast agent concentration ([Gd]) is assumed, even though this is a known simplification.
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- Cognitive impairment is prevalent in heart failure (HF) patients, and the study investigates sex differences in cognitive functioning linked to HF characteristics and brain injury.
- The research involved 162 HF patients who underwent neuropsychological assessments and brain MRI, revealing that women tend to perform better in global cognition and memory compared to men, despite differences in HF characteristics between sexes.
- Results showed that while some cognitive differences were associated with ischemic causes of HF, others, particularly in global cognition, persisted even after accounting for vascular brain injury factors.
White matter hyperintensity (WMH) shape is associated with long-term dementia risk in community-dwelling older adults, however, the underlying structural correlates of this association are unknown. We therefore aimed to investigate the association between baseline WMH shape and cerebrovascular disease progression over time in community-dwelling older adults. The association of WMH shape and cerebrovascular disease markers was investigated using linear and logistic regression models in the Age, Gene/Environment Susceptibility-Reykjavik (AGES) study (n = 2297; average time to follow-up: 5.
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- This study aimed to evaluate the prevalence of cerebrovascular MRI markers in patients hospitalized for COVID-19 compared to healthy controls without prior COVID-19 infection or hospitalization.
- Conducted as an observational cohort study, it involved brain MRIs done shortly after discharge and again after three months, focusing on various cerebrovascular issues.
- The results showed no significant difference in cerebrovascular MRI markers between COVID-19 patients and controls, with only a small percentage experiencing new cerebrovascular lesions after three months, suggesting limited impact of COVID-19 on these markers.