Publications by authors named "J de Boisanger"
Article Synopsis
- - Randomised control trial data suggest that stereotactic radiosurgery (SRS) is effective for patients with up to 4 brain metastases, with non-randomised data supporting its use in up to 10.
- - There is ongoing debate regarding the effectiveness of SRS for patients with more than 10 brain metastases, which this study addresses by analyzing data from 1181 patients.
- - Results indicate that median survival for patients with more than 10 brain metastases is similar to those with 2-4 metastases, suggesting these patients may also benefit from SRS treatment.
Brain metastases remain a challenging and feared complication for patients with cancer and research in this area has lagged behind research into metastases to other organs. Due to their location and the risks associated with neurosurgical biopsies, the biology underpinning brain metastases response to treatment and evolution over time remains poorly understood. Liquid biopsies are proposed to overcome many of the limitations present with tissue biopsies, providing a better representation of tumor heterogeneity, facilitating repeated sampling, and providing a noninvasive assessment of tumor biology.
View Article and Find Full Text PDFPembrolizumab has received approval in the UK as first-line monotherapy for recurrent and/or metastatic HNSCC (R/M HNSCC) following the results of the KEYNOTE-048 trial, which demonstrated a longer overall survival (OS) in comparison to the EXTREME chemotherapy regimen in patients with a combined positive score (CPS) ≥1. In this article, we provide retrospective real-world data on the role of pembrolizumab monotherapy as first-line systemic therapy for HNSCC across 18 centers in the UK from March 20, 2020 to May 31, 2021. 211 patients were included, and in the efficacy analysis, the objective response rate (ORR) was 24.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on the use of Contrast Clearance Analysis (CCA) with MRI in patients with lung cancer and brain metastases to improve the accuracy of distinguishing between treatment effects and tumor progression after stereotactic radiosurgery (SRS).
- In a retrospective analysis of 62 patients, CCA correctly identified the cause of ambiguous MRI changes in 80.6% of cases and helped maintain consistent diagnoses with follow-up imaging in most patients.
- The research suggests that CCA is a valuable tool in navigating diagnostic challenges in lung cancer treatment, influencing patient management decisions and improving treatment outcomes.
Predicting survival is essential to tailoring treatment for patients diagnosed with brain metastases. We have evaluated the performance of widely used, validated prognostic scoring systems (Graded Prognostic Assessment and diagnosis-specific Graded Prognostic Assessment) in over 1000 'real-world' patients treated with stereotactic radiosurgery to the brain, selected according to National Health Service commissioning criteria. Survival outcomes from our dataset were consistent with those predicted by the prognostic systems, but with certain cancer subtypes showing a significantly better survival than predicted.
View Article and Find Full Text PDF