Publications by authors named "J benoliel"
Article Synopsis
- * The relationship between stress and epilepsy is supported by neurobiological mechanisms, such as HPA axis dysfunction and altered neuroplasticity, that link the two conditions.
- * Future treatment approaches may involve collaboration between clinicians and scientists to develop personalized therapies, using data integration and advancements in machine learning and neuromodulation.
Article Synopsis
- The study investigated the role of brain-derived neurotrophic factor (BDNF) in epilepsy, specifically looking at its potential as a biomarker for epilepsy severity and related psychiatric conditions.
- It analyzed serum BDNF levels in epilepsy patients from four centers in France, while documenting various clinical characteristics and conducting psychiatric screenings.
- The results showed no significant correlation between serum BDNF levels and epilepsy features or depression, but found that the presence of anti-seizure medications (ASM) was linked to increased BDNF, especially with valproate and perampanel.
Article Synopsis
- - Stress can lead to depression, but individual vulnerability before stressful events plays a key role in how severely someone might be affected.
- - Researchers studied rats' sleep patterns before and after a stress event (social defeat) to identify specific sleep stages linked to vulnerability to depression using electroencephalogram recordings.
- - The study found early and late sleep biomarkers that can predict which rats are likely to become depressed, suggesting potential for developing treatments aimed at those at high risk of stress-induced depression.
The Relationship between Allostasis and Mental Health Patterns in a Pre-Deployment French Military Cohort.
Marion Trousselard Damien Claverie Dominique Fromage Christel Becker Jean-Guillaume Houël Jean-Jacques Benoliel
Eur J Investig Health Psychol Educ
October 2021
(1) Background: While a number of studies among military personnel focus on specific pathologies such as post-traumatic stress disorder (PTSD), anxiety, and depression, they do not address the cumulative impact on mental health of stressors related to the profession. The present study aims to determine the relationship between allostatic load and mental health status in a cohort of fit-for-duty soldiers prior to their deployment to Afghanistan. The aim is to better-define the consequences of stressor adjustment.
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- The study investigated the antiseizure properties of Anacyclus pyrethrum (AEAPR), a plant used in traditional medicine for epilepsy treatment, particularly in conditions of oxidative stress, such as social isolation.
- Using a pilocarpine model with socially isolated rats, researchers divided rats into treated (with AEAPR) and untreated groups, measuring their seizure activity and oxidative stress markers over time.
- Results showed that AEAPR significantly reduced seizure frequency, duration, and severity, while also lowering oxidative stress indicators, suggesting it has potential as an effective treatment for epilepsy even in adverse conditions.