25 years of quinacrine sterilization experience in Chile: review of 2,592 cases.

Objectives: To assess short-term side effects, long-term risks and efficacy of quinacrine sterilization (QS) in Chile.

Methods: Review experience of 2,592 cases sterilized with 2 or 3 transcervical insertions of 252 mg quinacrine as pellets since 1977; review the Chilean pre-clinical experience and epidemiological studies on cervical, endometrial and other cancers.

Results: Among 2,592 women who underwent QS, the total number of pregnancies was 119 (4.

Quinacrine sterilization: a retrospective.

Objective: To trace development of quinacrine sterilization (QS).

Methods: Review of published reports.

Results: The high prevalence of septic abortion among high parity women in Santiago, Chile, motivated Zipper to find a safe, inexpensive method of non-surgical female sterilization.

Quinacrine sterilization: a retrospective.

Objective: To trace development of quinacrine sterilization (QS).

Methods: Review of published reports.

Results: The high prevalence of septic abortion among high parity women in Santiago, Chile, motivated Zipper to find a safe, inexpensive method of non-surgical female sterilization.

25 years of quinacrine sterilization experience in Chile: review of 2,592 cases.

Objectives: To assess short-term side effects, long-term risks and efficacy of quinacrine sterilization (QS) in Chile.

Methods: Review experience of 2,592 cases sterilized with 2 or 3 transcervical insertions of 252 mg quinacrine as pellets since 1977; review the Chilean pre-clinical experience and epidemiological studies on cervical, endometrial and other cancers.

Results: Among 2,592 women who underwent QS, the total number of pregnancies was 119 (4.

Study of the conformational transition of A beta(1-42) using D-amino acid replacement analogues.

A critical event in Alzheimer's disease is the transition of Abeta peptides from their soluble forms into disease-associated beta-sheet-rich conformers. Structural analysis of a complete D-amino acid replacement set of Abeta(1-42) enabled us to localize in the full-length 42-mer peptide the region responsible for the conformational switch into a beta-sheet structure. Although NMR spectroscopy of trifluoroethanol-stabilized monomeric Abeta(1-42) delineated two separated helical domains, only the destabilization of helix I, comprising residues 11-24, caused a transition to a beta-sheet structure.