Publications by authors named "J Zakzuk"
Introduction: Invasive pneumococcal disease (IPD) remains a pediatric health challenge despite national vaccination efforts in Colombia. We described the socio-demographic, epidemiological, and clinical characteristics of children (<18 years of age) with IPD at a pediatric reference center in Bolívar, Colombia.
Methods: Descriptive cross-sectional study of all pediatric patients (under 18 years of age) diagnosed with IPD between 2016 and 2023.
Article Synopsis
- * The discovery of 26 B. tropicalis allergens, some cross-reactive with other mite species, complicates diagnosis and treatment options for allergies, though advancements in component-resolved diagnostics aid in this process.
- * Immunotherapy using B. tropicalis extracts is effectively implemented in various countries, but there is a challenge with the limited availability of standardized extracts, despite significant research contributions over the past five decades on allergen characterization and potential impacts of climate change.
Cost Analysis of Thromboprophylaxis in Patients at High Thromboembolic Risk with Enoxaparin, Dalteparin and Nadroparin in Colombia: A Systematic Literature Review-Based Study.
Clinicoecon Outcomes Res
November 2024
Purpose: To analyze the costs of high thromboembolic risk patients who require low molecular weight heparins (LMWHs) as a thromboprophylaxis strategy.
Methods: Cost analysis was conducted to assess LMWHs (enoxaparin versus comparators: nadroparin and dalteparin) as thromboprophylaxis for hospitalized patients with high thromboembolic risk in Oncology, General or Orthopedic Surgery, and Internal Medicine services from the healthcare provider's perspective in Colombia. A decision tree was developed, and the health outcomes considered in the analysis were deep vein thrombosis, major bleeding, pulmonary thromboembolism, and chronic pulmonary hypertension.
Article Synopsis
- Ascaris infection, a common soil-transmitted helminth, may exacerbate asthma and allergic reactions through its influence on immune responses, specifically group-2 innate lymphoid cells (ILC2).
- * The study involved comparing non-infected and Ascaris-infected individuals, analyzing ILC subsets, their activation markers, and the presence of specific antibodies.
- * Results showed that ILC2 activation markers were significantly higher in Ascaris-infected individuals, particularly those sensitized to a specific Ascaris antigen, suggesting a link between helminth infection and enhanced immune responses.
Article Synopsis
- A study investigates how the parasitic infection of Ascaris lumbricoides affects the immune system, particularly focusing on the role of B regulatory cells (Bregs) in infected individuals.
- In a helminth-endemic area of Colombia, researchers compared 18 A. lumbricoides-infected subjects with 11 non-infected individuals, measuring Breg frequencies and specific antibodies in their blood.
- Results showed that infected individuals had higher Breg levels and lower levels of certain antibodies, suggesting that A. lumbricoides infection leads to an immunosuppressive effect that varies based on infection intensity.