Communicating evidence-based information on the effects of health interventions to various types of recipients - a qualitative study on the perception of formats of information among lay and professional audiences.

Introduction And Objective: Considering the complexity of medical discourse, the enormous amount of information, including fake news, it becomes increasingly challenging to develop health literacy among the general population and to ensure efficient communication of scientific findings on the effects of health interventions to various types of recipients. We aimed to gain an in-depth understanding of how the various types of audiences perceive various formats for presenting data from Cochrane systematic reviews (SRs).

Material And Methods: We conducted focus group interviews with university employees, students, pharmacists, patients, caregivers, physicians, and nurses.

Perioperative lifestyle and nutritional interventions' details reporting in bariatric surgery trials according to the Template for Intervention Description and Replication (TIDieR) checklist: a cross-sectional study.

Background: Metabolic and bariatric surgery (MBS) is considered the most effective treatment for people with severe obesity, and certain interventions could enhance its long-term results. The complete reporting of interventions' details is necessary for their replication in clinical settings.

Objectives: To investigate the completeness of reporting of lifestyle and nutritional interventions applied in immediate perioperative period (30-days preoperatively and postoperatively) in patients undergoing MBS using the 12-item Template for Intervention Description and Replication (TIDieR) checklist, and to explore factors associated with compliant reporting.

Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology - A Potential Driver for Reducing/Replacing Laboratory Animals in the Future.

The first ONTOX Hackathon of the EU Horizon 2020-funded ONTOX project was held on 21-23 April 2024 in Utrecht, The Netherlands (https://ontox-project.eu/hackathon/). This participatory event aimed to collectively advance innovation for human safety through the use of Artificial Intelligence (AI), and hence significantly reduce reliance on animal-based testing.

Bacillus Calmette-Guérin (BCG) Vaccine in America and Overseas: A Narrative Review.

This narrative review examines the role of the Bacillus Calmette-Guérin (BCG) vaccine in global tuberculosis (TB) control efforts, with particular emphasis on the differences in vaccination policies between countries, such as the US, where routine BCG administration is not practiced. A significant complication of the BCG vaccine is false positive results in the tuberculin skin test (TST), often leading to misdiagnoses and unnecessary treatments. To address these issues, interferon-gamma release assays (IGRAs) have emerged as a more specific diagnostic tool that reduces false positives associated with prior BCG vaccination.

Isotonic medium treatment limits burn wound microbial colonisation and improves tissue repair.

Burn injuries undergo a complex healing process in which progressive spreading of epithelial damage can lead to secondary complications such as wound infection, which is a major driver of mortality among burn patients. We recently reported that burning larval zebrafish triggers dysregulated keratinocyte dynamics compared to mechanical injury. Here, we investigate keratinocyte behaviour following burn injury and the subsequent potential for microbial colonisation of burn wounds over time.