Original Article: Insensitivity of Platelet Aggregation to Inhibition by Prostaglandin I(2) (PGI(2)) and Prostaglandin E(1) (PGE(1)), and Reduced Platelet c-AMP Accumulation in Response to PGE(1) in Insulin-dependent Diabetic Patients.

In insulin-dependent diabetics (IDDM) and peripheral occlusive arterial disease (POAD), inhibition of platelet aggregation (PA) by PGI(2) and PGE(1) was reduced (p <0.02) compared with non-diabetics and POAD as well as with healthy subjects at a similar extent of PA (in the 3 groups). c-AMP content in resting platelets of IDDM and chronic renal failure was decreased (mean ± SD in pmo1/2.