Publications by authors named "J ZadraZil"
Background: Kidney transplantation is the preferred treatment for patients with end-stage renal disease, significantly preserving kidney function and patient quality of life. However, post-transplant diabetes mellitus (PTDM) is a common complication, occurring in approximately one-third of renal transplant recipients. This study aims to evaluate the role of pulse wave parameters in predicting PTDM and to identify other pre-transplant risk factors.
View Article and Find Full Text PDFAcute kidney injury due to gentamicin nephrotoxicity and specific miRNAs as biomarkers.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub
October 2024
Article Synopsis
- Gentamicin, an antibiotic used to treat infections, can cause acute kidney injury (AKI) due to its nephrotoxic effects, especially in patients on high doses or long-term therapy.
- Researchers are exploring non-protein-coding RNAs, particularly microRNAs (miRNAs), as potential biomarkers for diagnosing and monitoring gentamicin-induced AKI.
- Changes in miRNA expression related to inflammation, cell death, and oxidative stress have been observed in response to gentamicin exposure, indicating their potential role in assessing kidney injury severity.
Introduction: Immunoglobulin A1 (IgA1) with galactose-deficient -glycans (Gd-IgA1) play a key role in the pathogenesis of IgA nephropathy (IgAN). Mucosal-tissue infections increase IL-6 production and, in patients with IgAN, are often associated with macroscopic hematuria. IgA1-secreting cell lines derived from the circulation of patients with IgAN, compared to those of healthy controls (HCs), produce more IgA1 that has glycans with terminal or sialylated -acetylgalactosamine (GalNAc).
View Article and Find Full Text PDFOne of the common causes of acute kidney injury (AKI) is drug nephrotoxicity. A large group of drugs associated with AKI includes a considerable number of antimicrobials. Clinical manifestations range from mild forms of tubular damage to significant deterioration of renal function requiring renal replacement therapy.
View Article and Find Full Text PDFBackground: Through regulation of signaling pathways, microRNAs (miRNAs) can be involved in sepsis and associated organ dysfunction. The aims of this study were to track the 7-day time course of blood miRNAs in patients with sepsis treated with vancomycin, gentamicin, or a non-nephrotoxic antibiotic and miRNA associations with neutrophil gelatinase-associated lipokalin (NGAL), creatinine, procalcitonin, interleukin-6, and acute kidney injury (AKI) stage.
Methods: Of 46 adult patients, 7 were on vancomycin, 20 on gentamicin, and 19 on another antibiotic.