Publications by authors named "J Z Kubicek-Sutherland"

Article Synopsis
  • * The authors suggest new metrics to measure how well vaccines stimulate CD8 T cells and identify key viral parts that trigger immune response, considering genetic differences among people and viral changes.
  • * The proposed methods were tested successfully using proteins from the Ebola virus and SARS-CoV-2 vaccines, showing the effectiveness of their approach.
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Nanodiscs are discoidal lipoproteins that have often been used as vehicles to study membrane proteins in their native configuration. Nanodiscs have been primarily made from synthetic lipids. However, nanodiscs also offer a format by which native lipids can be studied in their natural configuration.

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Universal and early recognition of pathogens occurs through recognition of evolutionarily conserved pathogen associated molecular patterns (PAMPs) by innate immune receptors and the consequent secretion of cytokines and chemokines. The intrinsic complexity of innate immune signaling and associated signal transduction challenges our ability to obtain physiologically relevant, reproducible and accurate data from experimental systems. One of the reasons for the discrepancy in observed data is the choice of measurement strategy.

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Bacterial infections are an urgent public health priority. The application of mRNA vaccine technology to prevent bacterial infections is a promising therapeutic strategy undergoing active development. This article discusses recent advances and limitations of mRNA vaccines to prevent bacterial diseases and provides perspectives on future research directions.

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Article Synopsis
  • Viral pathogens can easily evolve and evade human immunity, making early detection crucial to prevent pandemics; the development of rapid and accurate diagnostics is essential but is challenged by the ability of RNA viruses to mutate quickly.
  • The innovative computational approach called FEVER (Fast Evaluation of Viral Emerging Risks) allows for broad biosurveillance, accurate outbreak diagnosis, and rapid mutation typing of viruses, specifically targeting sarbecoviruses and the SARS-CoV-2 spike variant.
  • FEVER assays showed impressive results with a 99.7% predicted positive rate for SARS-CoV-2 sequences and high sensitivity (92.4%) and specificity (100%) in clinical samples, proving effective for tracking and managing future viral outbreaks.
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