Publications by authors named "J Yazdany"
Background: Systemic lupus erythematosus (SLE) has numerous symptoms across organs and an unpredictable flare-remittance pattern. This has made it challenging to understand drivers of long-term SLE outcomes. Our objective was to identify whether changes in DNA methylation over time, in an actively flaring SLE cohort, were associated with remission and whether these changes meaningfully subtype SLE patients.
View Article and Find Full Text PDFObjective: Recent research has explored frailty in systemic lupus erythematosus (SLE) using multiple measures. We examined the agreement among frailty measures and the association of each with cross-sectional and longitudinal health outcomes.
Methods: We used data from the California Lupus Epidemiology Study (CLUES) to examine the following measures of frailty: Systemic Lupus International Collaborating Clinics (SLICC) Frailty Index (SLICC-FI), Short Physical Performance Battery (SPPB), and Fatigue, Resistance, Ambulation, Illness, and Loss of Weight (FRAIL) scale questionnaire.
Objective: To analyze the variability in new infliximab biosimilar starts as well as switching from bio-originator to biosimilar infliximab, across insurance payers and rheumatology practices nationally.
Study Setting And Design: Data came from Rheumatology Informatics System for Effectiveness, a national registry with electronic health records from over 1100 US rheumatologists. Key outcomes include ever use of a biosimilar, date of initiation, and date of switching.
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- Physical activity improves symptoms in people with systemic lupus erythematosus (SLE), but the underlying mechanisms were unclear until this study explored immune cell differences among active vs. inactive patients.
- A cohort of 123 SLE patients underwent analysis of immune cells and gene expression through advanced RNA sequencing, revealing that sedentary patients had greater CD4+ T cell lymphopenia and an overall proinflammatory gene expression profile.
- The study indicates that increased physical activity could reduce levels of proinflammatory cytokines and improve immune function in SLE patients, suggesting potential therapeutic benefits of regular exercise for this condition.