Transthyretin-Related Familial Amyloidosis Polyneuropathy with Spinal Cord Damage: A Case Report.

Introduction: Transthyretin protein-related familial amyloidosis polyneuropathy (TTR-FAP) is an autosomal dominant genetic disease caused by mutations in the TTR gene. The disease is characterized primarily by peripheral and autonomic nerve damage. Disease progression is associated with frequent involvement of the heart, lungs, kidneys, eyes, and other organs.

Huanglian Ganjiang Decoction alleviates DSS-induced colitis through suppressing inflammation and protecting intestinal barrier: from the perspective of disassembling prescriptions.

Ethnopharmacological Relevance: Huanglian Ganjiang decoction (HGD), which is composed of Chinese medicines with cold, warm, and astringent properties, has demonstrated significant therapeutic efficacy in ulcerative colitis (UC). However, the underlying mechanisms remain unclear, highlighting the need for a multi-faceted investigation. Disassembling prescriptions is a crucial approach for investigating compatibility mechanisms.

Evolution of interspecific interactions underlying the nonlinear relationship between active biomass and pollutant degradation capacity in bioelectrochemical systems.

This study proposes a switching operating mode that alternates between microbial fuel cell (MFC) and microbial electrolysis cell (MEC) to restore the biofilm activity and organic pollutant degradation capacity in bioelectrochemical systems (BESs) during prolonged operation. After the model switching, the toluene degradation kinetics in BESs equipped with graphite sheet (GS) and polyaniline@carbon nanotubes (PANI@CNTs) bioanodes were elevated by 2.10 and 3.

Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus.

Japanese encephalitis virus (JEV) is a neurotropic zoonotic pathogen that poses a serious threat to public health. Currently, there is no specific therapeutic agent available for JEV infection, primarily due to the complexity of its infection mechanism and pathogenesis. Extracellular vesicles (EVs) have been known to play an important role in viral infection, but their specific functions in JEV infection remain unknown.

FKBP10 Promotes the Muscle Invasion of Bladder Cancer via Lamin A Dysregulation.

Bladder cancer (BC) is a prevalent urinary malignancy and muscle-invasive bladder cancer (MIBC) is particularly aggressive and associated with poor prognosis. One of MIBC features is the nuclear atypia. However, the molecular mechanism underlying MIBC remains unclear.