Cu-Catalyzed Relay Functionalization of Alkenes: Diverse Synthesis of Diazidated Quinazolinones and Polycyclic Imidazoles.

A Cu-catalyzed relay process for the preparation of diazidated quinazolinone and polycyclic imidazole derivatives in which readily available alkene-tethered substrates undergo an addition/cyclization/C(sp)-H functionalization of alkene sequences with high efficiency is described. Various functionalized N-heteropolycyclic compounds were readily prepared in good yields with a broad substrate scope. Moreover, the direct azidation of the α-C(sp)-H bond of the corresponding N-heterocycles has been demonstrated on the basis of mechanistic studies, which provide an alternative late-stage functionalization approach for the derivatization of N-heterocyclic scaffolds.

Electrochemical In Situ Characterization Techniques in the Field of Energy Conversion.

With the proposal of the "carbon peak and carbon neutrality" goals, the utilization of renewable energy sources such as solar energy, wind energy, and tidal energy has garnered increasing attention. Consequently, the development of corresponding energy conversion technologies has become a focal point. In this context, the demand for electrochemical in situ characterization techniques in the field of energy conversion is gradually increasing.

Infrared Aircraft Detection Algorithm Based on High-Resolution Feature-Enhanced Semantic Segmentation Network.

In order to achieve infrared aircraft detection under interference conditions, this paper proposes an infrared aircraft detection algorithm based on high-resolution feature-enhanced semantic segmentation network. Firstly, the designed location attention mechanism is utilized to enhance the current-level feature map by obtaining correlation weights between pixels at different positions. Then, it is fused with the high-level feature map rich in semantic features to construct a location attention feature fusion network, thereby enhancing the representation capability of target features.

Data on hydrodynamic flow and aspiration mechanisms in a patient-specific pharyngolaryngeal model with variable epiglottis angles.

This dataset comprises a comprehensive collection of videos and images illustrating the fluid dynamics of swallowing and aspiration in a patient-specific pharyngolaryngeal model with varying epiglottis angles. The data also includes the physical properties of the fluids used, comprising dynamic viscosity, surface tension, and contact angle. Videos under varying swallowing conditions were collected to investigate the mechanisms underlying aspiration.

Identification of potential therapeutic targets for Alzheimer's disease from the proteomes of plasma and cerebrospinal fluid in a multicenter Mendelian randomization study.

Background: Certain peripheral proteins are believed to be involved in the development of Alzheimer's disease (AD), but the roles of other new protein biomarkers are still unclear. Current treatments aim to manage symptoms, but they are not effective in stopping the progression of the disease. New drug targets are needed to prevent Alzheimer's disease.